The adjusted Cox proportional hazard model revealed that men with total cholesterol of 280 mg/dL or greater were 2.21 (95% confidence interval (CI), 1.59–3.09) times more likely to have a CHD event than men with total cholesterol from 160 through 199mg/dL men with diabetes were 1.63 (95% CI, 1.35–1.98) times more likely to experience a CHD event than men without diabetes. The ACLS cohort produced similar hazard ratios to the FHS. Multivariable-adjusted hazard ratios generated from ACLS analysis were compared with the application of FRS to the Framingham Heart Study (FHS). During the 12-year follow-up 587 CHD events occurred. CHD events included self-reported myocardial infarction or revascularization or death due to CHD. Our study consisted of 34,557 men who attended the Cooper Clinic in Dallas, Texas, for a baseline clinical examination from 1972 through 2002. We hypothesize that the FRS will be significantly predictive of CHD events among men in the Aerobics Center Longitudinal Study (ACLS) population. The Framingham Risk Score (FRS) was developed to help clinicians in determining their patients’ CHD risk. DOI:Ĭoronary heart disease (CHD) remains a leading cause of death in the United States. Factors Related to Coronary Heart Disease Risk Among Men: Validation of the Framingham Risk Score. Suggested citation for this article: Gander J, Sui X, Hazlett LJ, Cai B, Hébert JR, Blair SN. Jennifer Gander, MSPH Xuemei Sui, MD, MPH, PhD Linda J Hazlett, PhD Bo Cai, PhD James R.
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